Monographs on Anesthesiology 3. Muscle Relaxants

Use of muscle relaxants.

On Benzofuroindole Analogues as Smooth Muscle Relaxants

At least two laboratories have independently reported the synthesis of benzofuroindole compounds having potential therapeutic implications in many disease states including those that involve smooth muscle hyperactivity. Through a series of in vitro screenings, they demonstrated the efficacy (and selectivity) of these compounds to potentiate large conductance calcium- (Ca²⁺-) activated K⁺ (BK(Ca...

Muscle relaxants and antispasticity agents.

Muscle relaxants make up a heterogeneous group of agents and can have a clinically significant role in the treatment of chronic muscle pain. These medications are not without possible serious side effects; hence, care should be taken in deciding on their appropriateness and ongoing monitoring performed, if prescribed.

Muscle relaxants and Bier's block.

Sir We are grateful for the opportunity to reply to your correspondent. If no less an authority than Professor J. M. Hunter can write a sentence beginning 'With the advent of the two new non-depolarizing muscle relaxants, atracurium and vecurionium . . .' (Hunter, 1987), we feel we may use the same expression. Ethical committee approval for the addition of atracurium to Bier's blocks was obtain...

Muscle Disorders and the Relaxants.

1 Muscle weakness is a feature of many illnesses but the present discussion will be confined mainly to conditions in which it is a manifestation of defects in the anterior horn cells, the motor nerves, the neuromuscular junction, or the muscle itself. The pathogenesis of these disorders is often ill-understood and more than one component of the neuromuscular system may be involved. Moreover, kn...